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- Unit Price：
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Original
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Code：706815-001
Original
- VONOSAP Pack 800 : 7 sheets（Primary treatment）
- $174.99
Up to 4 pieces per person
10% discount for total amount over $100
shipping schedule : 5 to 10 working days after payment.
warehouse：Japan1
Manufacturer ：Takeda Pharmaceutical
Brand ：Takeda Pharmaceutical
JAN Code：----
◆ Eradicating Agent for HELICOBACTER PYLORI（Primary treatment）
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Description
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VONOSAP is a triple-drug blister pack combining the acid suppressant ((also called a potassium-competitive acid blocker (P-CAB) based on its mechanisms of action)) TAKECAB® tablet (generic name, vonoprazan fumarate; hereafter “TAKECAB”) developed by Takeda, “Amolin® capsule” (generic name, amoxicillin; hereafter “Amolin”) and “Clarith® tablet” (generic name, clarithromycin) for primary eradication of H. pylori.
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Presentation
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7 sheets for 7 days
1 sheet per day
1．Takecab : Vonoprazan fumarate 20mg x 2 tablets
2．Clarith : Clarithromycin 200mg x 4 tablets
3．Amolin : Amoxicillin hydrate 250mg x 6 capsules
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Feature
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Per day：
1. Takecab Tablets 20mg x 2tablets
faint red elliptical tablet, major diameter: 11.2 mm, minor diameter: 6.2 mm, thickness: about 3.9 mm.
2. Clarith tab. 200: x 4 tablets
white tablet, diameter: about 8.6 mm, thickness: about 5.4 mm.
3. AMOLIN CAPSULES 250: x 6 capsules
capsule with white cap and white body, major diameter: 18.8 mm, minor diameter: 6.3 mm.
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Active Ingredients
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Per day：
1．Takecab : Vonoprazan fumarate 20mg x 2tablets
2．Clarith : Clarithromycin 200mg x 4 tablets
3．Amolin : Amoxicillin hydrate 250mg x 6 capsules
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Effect/Efficacy
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Takecab Tablets 20mg inhibits gastric mucosal proton pump to suppress gastric acid secretion, thereby enhancing the antibacterial effects of the antibiotics (Clarith tab. 200 and AMOLIN CAPSULES 250), while Clarith tab. 200 and AMOLIN CAPSULES 250 demonstrate their antibacterial effects against Helicobacter pylori.
It is usually used to treat Helicobacter pylori infection of gastric ulcer, duodenal ulcer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura or the stomach after endoscopic treatment of early-stage gastric cancer, and to treat Helicobacter pylori gastritis.
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Usage/Dosage
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In general, for adults, take 1 tablet of Takecab Tablets 20mg (20 mg of vonoprazan), 1 tablet of Clarith tab. 200 (200 mg [titer] of clarithromycin) and 3 capsules of AMOLIN CAPSULES 250 (750 mg [titer] of amoxicillin hydrate) at a time, twice a day, for 7 days.
The dosage of Clarith tab. 200 may be increased as required but the maximum daily dose is 2 tablets (400 mg [titer] of clarithromycin) at a time, twice a day.
This medicine is supplied in pack sheets. Each sheet contains one morning and one evening doses (good for one day) (each dose: 1 tablet of Takecab Tablets 20mg, 2 tablet of Clarith tab. 200 and 3 capsules of AMOLIN CAPSULES 250). Strictly follow the instructions.
If you miss a dose, take the missed dose as soon as possible. However, if it is less than 5 hours to the time for your next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.
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Cautions
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■ Before using this medicine, be sure to tell your doctor and pharmacist:
If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have infectious mononucleosis, renal disorder, heart disease or liver disorder.
If you or any of your parents and siblings is predisposed to allergic symptoms such as bronchial asthma and rash.
If you are in a poor oral feeding state.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
■ Storage conditions and other information:
Keep out of reach of children. Store away from direct sunlight, heat and moisture.
Discard the remainder. Do not store them.
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Contraindication
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Possible adverse reactions to this medicine:
These medicines may cause gastrointestinal symptoms such as diarrhea, taste abnormality or rash. Take the following measures according to symptoms.
1) In case of gastrointestinal symptoms such as loose stool and mild diarrhea or taste abnormality
Continue taking this medicine to complete the dosing schedule (7 days); do not reduce dosage or the number of medication at your discretion.
If symptoms become worsened, however, consult with your doctor or pharmacist.
2) In case of diarrhea associated with fever or abdominal pain, mucus- and/or blood-containing diarrhea or rash
Stop taking this medicine immediately and contact your doctor or pharmacist.
The most commonly reported other adverse reactions include stomatitis, stomach discomfort, abdominal enlarged feeling, itching, constipation, edema, fever, nausea, loss of appetite, vomiting, gastric distress, abdominal pain, hallucination, disorientation (inability to be cognizant of time, location or name), consciousness disorder, delirium, mania, shivering, numbness, tinnitus, decreased hearing, olfactory abnormality, oral erosion, tooth discoloration, muscle pain, candidiasis, palpitation and hypoglycemia. If any of these symptoms occur, consult with your doctor or pharmacist.
